Very few Republicans seem to be tired of Trump, unless defected to the Dems. Most of the people who are tired of Trump are a variety of Democrats ranging from centrists to progressives. Besides the MAGA folks there are others who look insightful but are Trump hold-outs who are ideologue die-hards for Trump. (My sister is one of these people. Outside normal and pro-life BTW, inside fanatical about Trump - though not into the Q-anon BS.)
Given Trump's obsessive-compulsive behaviors re: winning and refusing to lose, he will run again - unless tried and convicted of Jan 6th crimes. If he runs I think it will be a shit-show in the Republican party which may implode with a DeSantis - Trump rivalry. Many but not all liberals have a certain logic set which is alien to Trump ideologues who have a very different mindset based on premises couched in a mythic past of a white upper class highly educated American Dream who are fearful (maybe terrified of the future) individualist types who want to hang onto their money and power at the expense of middle classes and don't give a shit about others who are not them (at least as groups).
So Pipe Dream. Not for many women - maybe. Many women will go against Trump since he appointed judges that Overturned Roe v Wade and are pissed (as am I). Anyway, probably too much, right?
People will vote their pocketbooks which means probably Republicans. The Bi-Partisan Bills for Medicare to begin to negotiate prices with Big Pharma and other measures might sway some back to the Dems. So pipe dream only if the Dems retain the House and stay where their at in the Senate.